Monoclonal free light chains (FLCs) are important disease biomarkers in patients with plasma cell-proliferative disorders. The increasing evidence for clonal di.
What are free light chains? 5. The role of the Freelite assay. 5. Normal vs. abnormal light chain levels. 7. The kappa/lambda ratio. 7. How can the Freelite assay.
Free light chain assays measure the amount of light chains in the blood. Light chains, known specifically as immunoglobulin light chains, are small molecules. Dr Judith Finlay - Understanding the Serum Free Light Chain Assays Ratios that border on the cutoff limits of the reference interval may be misclassified as normal or abnormal, and one might expect other discordant results by simply repeating the assay on those samples with ratios close to Free light chains reference limits. Immunoglobulin Free Light Chains, Serum. For assays detecting homogeneous antigens, monoclonal antibodies Mabs are very successful. In AL amyloidosis a higher level of sFLCs at diagnosis predicts for a higher risk of death [ Kumar et al. Serum Free Light Chains.